In order to improve the life of cold stamping die and reduce the manufacturing cost of die, the die manufacturing technology of laser cladding wear resistant layer on cast steel matrix surface was proposed. Firstly, three kinds of laser cladding materials were designed and the corresponding laser cladding process parameters were formulated. Laser cladding experiments were carried out on 45 cast steel matrix with the three materials by laser cladding equipment. Then, the physical and metallographic analyses of cladding samples were conducted. The results show that α-Fe, Fe-Cr intermetallic compounds, Fe-Ni solid solution, Ni-Cr-Fe solid solution and other phases are mainly found in the cladding layer of the first material, which forms solid solution strengthening and improves the hardness of cladding metal. The cladding layer of the second material mainly contains martensite, precipitated phase Fe-Cr, FeV, MnV, etc. The hardness and strength of martensite are improved, and the precipitated material at the grain boundary has the effect of dispersion strengthening, which significantly improves the hardness and strength of the material. The cladding layer of the third material mainly contains martensite, Cr7C3, Mn23C6 and other phases. The microstructure of the material has a reticular structure, and the carbide of reticular grain boundary wraps martensite, which can significantly improve the microhardness and strength of the material. Finally, the hardness, friction coefficient and wear resistance of the three materials were analyzed. It determines that the third material has the highest microhardness, the best wear resistance and the lowest friction coefficient. When the third material is coated on the edge of a cold stamping and trimming die, the die life is significantly increased.