Based on the experimental data, a TC6 titanium alloy model of dynamic recrystallization was established, and in order to have the function to simulate microstructure evolution, a secondary development to large-scale simulation software Deform was carried out. Through a cylinder upsetting simulation, the reliability of the secondary developed software was verified. Preforging process of TC6 titanium alloy blade was simulated under different deformation temperatures and deformation speeds using the secondary developed software.The influence on the grain size and distribution of the different deformation temperatures and deformation rates on the blade during pre\|forging was analyzed. Simulation results show that the average grain size of main deformation zone of forging is slightly increased, the difference between grain size is reduced, and the grain distributes evenly as the deformation temperature rising and with the deformation rate increasing, the distribution of average grain size distributes more uneven. Therefore, the appropriate deformation temperature and deformation speed can make forgings with good comprehensive mechanical properties.