Wrinkling is one of the main defects in rubber forming process. There are a range of sheet metal bulkheads like fish head installed in the leading edges of large aircrafts，which are of large curvature and high flange, especially easy to wrinkle in forming. So wrinkling control is the key problem to be solved. Therefore, a finite element model of rubber forming was built by software PAMSTAMP, and the wrinkling defects of sheet metal parts with large curvature and high flange were analyzed. Furthermore, the influences of die structure with the side pressure block or blankholder on the wrinkling reduction technology in the rubber forming were investigated, and the optimum values of expanded blank, die structure and rubber hardness were determined. Through experimental verification, a rubber forming method was developed, which could fully manufacture blank expanded without allowance to convex bending parts. Thus, precise rubber forming without wrinkle of sheet metal parts with large curvature and high flange was realized，which provided a reference for the manufacturing of large aircraft sheet metal parts.