Micro-channel tube has characteristics of large quantity in channel number, small channel size, thin wall thickness and high dimensional accuracy etc., and it is very difficult to process. Then, the flow uniformity along the width direction, the filling and welding quality at the channel area in the continuous extrusion of micro-channel tube products were improved obviously by continuous extrusion method of double extrusion, adding metal guide plate, optimizing die structure,processing method and extrusion process. Moreover, it was solved the problems of dimensional tolerance and invalid due to insufficient strength of die core, failure of squeezing due to excessive overflow in the extrusion process. At last, the micro-channel tubes with the thickness of 2.2 mm, the width of 45 mm, and 52-hole miniature were carried out, and the design requirements of size and structure were sufficiently met.