In order to solve the problems of high production cost and low processing efficiency of dimpled heat exchange tube, a extrusion device for multi-pitch rapid forming was designed, and the influences of extrusion depth D, extrusion interval P and indenter radius R on the forming performance were investigated by numerical simulation. Then, based on the response surface method, a multiple regression equation of extrusion forming parameters and forming mechanical properties was established. The results show that the regression equation is reliable and effective, which can be used to predict the mechanical response of dimpled heat exchange tube. The response surface method is used to study the influences of extrusion forming parameters on the stress, equivalent plastic strain and extrusion force of bare tube, and a response surface model for predicting the mechanical response of dimpled heat exchange tube is obtained. Furthermore, a binary interaction regression prediction model is established, and the error between the predicted and simulated values is less than 0.5%, which can more intuitively reflect the influence of various extrusion forming parameters on the forming mechanical properties, and is helpful for the structural design and manufacture of dimpled heat exchange tube, which provides theoretical support for the structural design and manufacture of dimpled heat exchange tube.