Hot tensile experiments were conducted on Fe-Cr-Mo-Mn steel by a Gleeble thermal simulation test machine to investigate the influence of process parameters on the dynamic recrystallization (DRX) behavior of material. However, DRX during the plastic deformation process induced a softening effect in the material, leading to a decrease in dislocation density and deformation energy, as well as a reduction in flow stress and strain hardening, thus impacting the mode of void evolution. Therefore, considering the influence of DRX on void evolution during hot processing, an extended GTN-Thomason ductile fracture model was developed, which introduced a dynamic recrystallization volume fraction Xdrx and applied the void volume fraction to describe damage accumulation, and the change in void nucleation strain and critical void size ratio was described by exponential functions. The developed model was used in finite element simulation, and a hybrid numerical-experimental method was used to calibrate its parameters. Experiments at various stress states and temperatures were designed to verify the validity of the ductile fracture model.