Mastering the forming distribution law of barrel forgings is the prerequisite for ensuring the forming quality of barrel forgings and plays a decisive role in the service performance of the new generation large-caliber artillery barrels. Therefore, a research method combining physical simulation and numerical simulation was adopted. Then, for the problems existing in the artillery barrel blank forming process of Cr-Ni-Mo-V steel produced by the electroslag remelting process, a new forming process flow was proposed, namely the composite process of closed upsetting, reverse extrusion punching and extrusion forming. The results show that the closed upsetting effectively breaks up the coarse dendrites and improves the uniformity of structure. The reverse extrusion punching helps to form a hollow thick-walled barrel blank, but it is easy to cause defect expansion when there are internal defects. The extrusion forming process ensures the uniformity of tube wall thickness and the stability of metal flow rate. The consistency of the physical and numerical simulation results verifies the effectiveness of the proposed process and provides important theoretical basis and technical support for the actual production.