Abstract: The fracture failure performance and characterization model of high-strength dual-phase steel DP780 were analyzed. Firstly, the static and dynamic mechanical properties curves were fitted by the hybrid hardening model and Johnson-Cook high strain rate constitutive model, and five fracture failure specimens were designed and the ultimate plastic strain at fracture was obtained by experiments. Secondly, simulation analysis was conducted on each specimen, taking the minimizing error of load-displacement curve as the goal, the coefficients of the hybrid hardening model were optimized to extract the stress triaxiality of fracture area, and the failure curve was fitted by the Johnson-Cook model. Finally, the model was verified by the perforation experiment of each specimen. The results indicate that the optimal adjustment coefficient for the Swift and Hockett-Sherby hybrid hardening model is 0.685, the load-displacement curves of different specimens have a high degree of coincidence with the experiment results, and the errors of maximum load and maximum failure displacement do not exceed 5%, and the locations of fracture area are basically consistent. Thus, the research proves that the constructed model has a good characterization of mechanical properties and fracture performance for the material and is applied to the whole vehicle collision simulation.