The frame is one of important components of automobile and all parts of the vehicle are installed on the frame through the holes in longitudinal beam of frame. The overall arrangement, quality control and production efficiency of longitudinal beam of frame were affected by the machining of holes in longitudinal beam of automobile frame. The application, class and overall arrangement of common holes of longitudinal beam for truck frame were studied, and the relationship between frame and parts, and parts and mounting holes were also elaborated. The process methods of holes in longitudinal beam were analyzed from the aspects of scale, quality and investment, etc. And the improvement suggestions for the frequently question about design were provided. The results show that the diameter of holes in longitudinal beam of frame must be standardized and their arrangement must be normalized. The accuracy of group holes should achieve to±0.3 mm, and the number of holes for each beam should not exceed 500. The flexible manufacturing facilities, such as CNC punching, ect., are chosen preferentially, and the procession period from receiving drawing of longitudinal beam to accomplishment of hole process should be kept within 5 days as soon as possible.