In order to study the hot deformation behavior of extruded ZK61M magnesium alloy, the hot compression test under the condition of the temperature of 300-450 ℃ and the strain rate of 0.001-0.5 s-1 was carried out by Gleeble3800 thermal simulator, and the effects of deformation temperature and strain rate on the flow stress were analyzed. And the deformation activation energies of cast magnesium alloy and extruded magnesium alloy were studied and compared, and the constitutive equation was finally applied to the simulation software for quantitative validation. The results show that the flow stress of alloy is negatively correlated with the deformation temperature and positively correlated with the strain rate. The stressstrain curves are found to have the characteristics of dynamic recovery and recrystallization. Compared with the cast magnesium alloy of similar components, the deformation activation energy of MgZnZr wrought magnesium alloy is lower, like ZK61M, it is about 120 kJ·mol-1. And for MgZnZr magnesium alloys, the alloy composition is the main factor that determines the value of deformation activation energy, when the compositions are same, the deformation activation energies are basically similar. Both the simulated curve and the test curve have the same trend, and the peak stresses are [JP2]closed. Applied by Arrenhenius equation, the deformation activation energy of extruded ZK61M magnesium alloy is Q=122.685 kJ·mol-1, and the stress exponent is n=4.13652,[JP] which provides theoretical guidance for the thermal processing parameters and preparation of MgZnZr wrought magnesium alloy.