In order to improve the performance and production efficiency of a complex irregular valve body, a multi-directional die forging production process was designed, and through establishing a material compression simulation model and a multi-directional die forging finite element analysis model at high temperature, the forming process of irregular valve body was simulated by software Deform-3D, and the influences of different mold loading methods on forming results of valve body, temperature distribution of value body, load changes of various punches, minimum clamping force and various mold temperatures were analyzed. The results show that the first loading mode is difficult to form, and is easy to produce burr and incomplete forging defects, the second loading mode is easy to produce folding defect, while the third and fourth loading modes can effectively avoid forming defects, and the fourth loading mode is more beneficial to improve the valve body quality and the mold life. Finally, the valve body forming tests under various loading modes were carried out by the multi-directional die forging hydraulic press, and the correctness of the analysis process was verified through the comparison between the test and simulation results. At the same time, the valve body forgings with smooth surface, qualified size, uniform fiber streamline and without defects such as folds and burrs were obtained under the appropriate process. Thus, this research can effectively promote the development of various valve body production processes.