For the problem that magnesium alloy was difficult to form at room temperature due to its typical close-packed hexagonal structure, ZK61 magnesium alloy sheet with high tensile strength and elongation was obtained through a combination process of multi-pass synchronous hot rolling and asynchronous warm rolling, and combined with the finite element simulation method of macroscopic rolling, the plastic deformation mechanism during the rolling process was analyzed in detail. The results of the tensile test show that as the rolling progresses, the anisotropy of sheet becomes weaker and the mechanical properties continue to be improved, and the tensile strength reaches 398.9 MPa and the elongation reaches 30.4%. The simulation results show that during the synchronous rolling, the maximum equivalent stress value increases slightly as the rolling progresses, while the maximum equivalent stress value during the asynchronous rolling gradually decreases as the rolling progresses. The equivalent plastic strain of rolled piece in the first few passes of synchronous rolling is not uniform, but as the rolling progresses and the subsequent asynchronous rolling, the plastic strain of sheet gradually becomes uniform.